Colorectal cancer: From prevention to personalized medicine

Table 3 Fecal DNA markers for advanced adenoma and colorectal cancer n (%)

Marker	Study	Sensitivity		Specificity
		CRC	Adenoma > 1 cm
Meth vimentin	Chen et al[166]	43 (46)	-	178 (90)
	Itzkowitz et al[167]	29 (73)	-	106 (89)
	Li et al[168]	9 (41)	9 (45)	63 (95)
Meth SFRP2	Huang et al[169]	49 (94)	11 (53)	23 (96)
	Wang et al[170]	60 (87)	21 (62)	28 (93)
Meth TFPI2	Glöckner et al[171]	36 (76)	4 (21)	-
Meth ITGH4	Ausch et al[172]	-	9 (69)	22 (79)
Meth Spastic paraplegia-20	Zhang et al[173]	77 (80)	-	30 (100)
Meth PHACTR3	Bosch et al[174]	(50-60)	(17-29)	(92-98)
Meth TFPI2, long DNA	Zhang et al[175]	52 (87)	4 (44)	25 (83)
APC, KRAS, p53, long DNA	Imperiale et al[102]	16 (52)	84 (12)	1344 (94)
APC, KRAS, p53, long DNA	Alhquist et al[103]	3 (25)	47 (8)	2246 (96)
APC, KRAS, Meth vimentin	Alhquist et al[103]	11 (58)	55 (45)	63 (84)
Meth SFRP2, HPPI, MGMT	Huang et al[169]	50 (96)	15 (71)	23 (96)
Meth APC, ATM, hMLH1, sFRP2, HLTF, MGMT, and GSTP1	Leung et al[176]	15 (75)	17 (68)	27 (90)
Meth vimentin, long DNA	Itzkowitz et al[167]	68 (83)	6 (86)	298 (82)
Meth RASSF2 or SFRP2	Nagasaka et al[177]	63 (75)	25 (44)	101 (89)
Meth BMP3, hDNA, KRAS, APC	Zou et al[100]	67 (91)	21 (78)	85 (85)
Meth vimentin, MLH1, MGMT	Baek et al[178]	45 (75)	31 (60)	32 (87)
Meth RARB2, p16INK4a, MGMT, APC	Azuara et al[179]	16 (62)	8 (40)	20 (100)
KRAS, a actina Meth NDRG4, BMP3, vimentin, TFPI2	Ahlquist et al[107]	214 (85)	72 (54)	264 (90)
β-actin, KRAS, meth BMP3 and NDRG4, fecal hemoglobin	Lidgard et al[105]	91 (98)	48 (57)	139 (90)

Meth: Methylation; CRC: Colorectal cancer; APC: Adenomatous polyposis coli gene.