Antitubercular therapy in patients with cirrhosis: Challenges and options

Table 3 Proposed treatment according to stage of liver disease

Child’s status	Treatment
A	Two hepatotoxic drugs can be used namely isoniazid and rifampicin with/without pyrazinamide (low dose). Duration 6-9 mo
B	Ideally one hepatotoxic drug is used in combination. Pyrazinamide generally avoided Duration generally 9-12 mo
C	No hepatotoxic drugs to be used. Can use second-line drugs like streptomycin, ethambutol, fluoroquinolones, amikacin, kanamycin for extended duration of 12 mo or more. Role of aminoglycosides may be limited due to reduced renal reserve in these patients