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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. May 21, 2014; 20(19): 5737-5745
Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5737
Table 1 Hemostasis changes in chronic liver disease patients
Factors favoring anticoagulant stateFactors favoring prothrombotic state
Thrombocytopenia (decreased thrombopoietin, splenic sequestration)Decreased liver synthesis of antithrombin III, protein C, protein S
Thrombocytopathy (impaired platelet function)Elevated von Willebrand factor levels
Vitamin K deficiencyIncreased factor VIII levels
Decreased synthesis of coagulation factors including Factor II, VII, IX, X, V, fibrinogenGenetic predispositions like Factor V Leiden
Reduced clearance of tissue plasminogen activator