Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development

Table 2 Studies that examined histological improvements with a follow-up duration of more than 5 years after Helicobacter pylori eradication[129-134]

Ref.	Authors	Year	Country	Number of patients	Study design	Observation period (yr)	Gastric atrophy		Intestinal metaplasia
							Antrum	Corpus	Antrum	Corpus
129	Forbes	1996	Australia	54	Prospective	7.1	No		No
130	Ito	2002	Japan	22	Prospective	5.0	Yes	Yes	Yes	Yes
131	Zhou	2003	China	552	RCT	5.0	No	No	Yes	No
132	Leung	2003	Hong Kong	435	RCT	5.0	ND		Yes
133	Vannella	2010	Italy	300	Observational	5.2	No	Yes	No	Yes
134	Kodama	2012	Japan	323	Prospective	10.0	Yes	Yes	No	Yes

RCT: Randomized control trial.