New serological markers in pediatric patients with inflammatory bowel disease

Table 3 Association of the new serologic markers with phenotype in pediatric Crohn’s disease

Marker	CD phenotype	Ref.
Anti-OmpC Anti-CBir1 Anti-I2 ASCA	Complicated disease behavior CD-related surgery	[10,26]
gASCA	Early disease onset	[301,31]
	Ileal disease location
	Complicated disease behavior Perianal disease
	CD-related surgery
ACCA	Complicated disease behavior CD-related surgery	[30]1
ALCA	Ileal disease location	[301,31]
	Complicated disease behavior CD-related surgery
AMCA	Complicated disease behavior perianal disease	[301,31]
Anti-L	Ileal disease location	[301,31]
	Complicated disease behavior Perianal disease
	CD-related surgery
Anti-C	Complicated disease behavior Perianal disease	[30]1
	CD-related surgery
Anti-GP2 with ASCA	Early disease onset	[45]1
	Ileal location
	Complicated behavior
	Perianal disease

¹Mixed pediatric and adult cohort. Anti-OmpC: Antibodies against outer membrane porin C of Escherichia coli; Anti-CBir1: Antibodies against bacterial flagellin CBir1; Anti-I2: Antibodies against the Pseudomonas-associated sequence; ASCA: Antibodies against Saccharomyces cerevisiae; AMCA: Anti-mannobioside carbohydrate antibodies; ALCA: Anti-laminaribioside carbohydrate antibodies; ACCA: Anti-chitobioside carbohydrate antibodies; Anti-L: Anti-laminarin carbohydrate antibodies; Anti-C: Anti-chitin carbohydrate antibodies; Anti-GP2: Antibodies against glycoprotein 2.