MicroRNAs in colorectal cancer as markers and targets: Recent advances

Table 1 Colorectal cancer-associated microRNAs with identified targets

MiR (family)	Role/potential	Identified targets	Ref.
9	ON	E-cadherin	[36,81,82]
16	TS	COX-2, cyclin D1, survivin, CDK6	[84-86]
17	ON	RND3, P130	[18,42-45]
21	ON	PDCD4, RhoB, TGFBR2	[10-30]
22	TS	p21	[90-93]
31	ON	RASA1	[14,17,35-38]
33a	TS	Pim-1	[67]
34 family	TS	Axin2	[33,70,101-103]
92a	ON	BIM	[14,26,39,40-43]
95	ON	Nexin 1	[106]
139	TS	RAP1B, IGFR-1	[37,121,122]
143	TS	HK2, MACC1	[28,37,53,59-65]
145 family	TS	PAK4, NRAS, IRS1	[14,28,53,60,64,66-68]
148 family	TS	Bcl-2, CCK-2 receptor	[69-72]
155	ON	Claudin-1	[30-33]
215	TS	DTL	[20,55,73-75]
320a	TS	Neuropilin 1, β-catenin	[147,148]
339-5p	TS	PRL-1	[151]
342	TS	DNMT1	[152]
365	TS	Cyclin D1, Bcl-2	[155]
373	TS	RAB22A	[157]
499-5p	ON	FOXO4, PDCD4	[162]
506	ON	PPARα	[164]
1915	TS	Bcl-2	[170]
Let-7 family	TS	MMP11, PBX3	[24,38,52-57]

TS: Tumor suppressor; ON: Oncogene; COX-2: Cyclooxygenase-2; CDK6: Cyclin-dependent kinase 6; RND3: Rho family GTPase 3; PDCD4: Programmed cell death 4; TGFBR2: Transforming growth factor beta receptor 2; RASA1: RAS p21 protein activator 1; BIM: Bcl-2 interacting mediator of cell death; RAP1B: RAS related protein 1b; IGFR-1: Insulin-like growth factor receptor-1; HK2: Hexokinase 2; MACC1: Metastasis associated in colon cancer 1; PAK4: p21 protein-activated kinase 4; NRAS: Neuroblastoma RAS viral oncogene homolog; IRS1: Insulin receptor substrate 1; CCK-2: Cholecystokinin-2; DTL: Denticleless E3 ubiquitin protein ligase homolog; PRL-1: Phosphatases of regenerating liver-1; DNMT1: DNA methyltransferase 1; FOXO4: Forkhead box O4; PDCD4: Programmed cell death 4; PPARα: Peroxisome proliferator-activated receptor alpha; Bcl-2: B-cell leukemia/lymphoma 2; MMP11: Matrix metallopeptidase 11; PBX3: Pre-B-cell leukemia homeobox 3.