Staging systems of hepatocellular carcinoma: A review of literature

Table 2 Variables included in the main prognostic systems

Variables	Prognostic scores
	Okuda[13]	CLIP[14]	GRETCH[21]	BCLC[16]	CUPI[23]	JIS[24]	Tokyo[22]
Child-Pugh score		X		X		X
Ascites	X				X
Albumin	X						X
Total Bilirubin	X		X		X		X
Alkaline phosphatase			X		X
Alpha-fetoprotein		X	X		X
Tumor size	X	X		X			X
Numbers of nodules		X		X			X
TNM stage					X	X
Portal vein thrombosis		X	X	X
Metastasis				X
Portal hypertension				X
Presence of symptoms and/or General Status			X	X	X

CLIP: Cancer of the Liver Italian Program; GRETCH: Groupe d’Etude et de Traitement du Carcinome Hépatocellulaire; BCLC: Barcelona Clinic Liver Cancer; CUPI: Chinese University Prognostic Index; JIS: Japan Integrated Staging Score; TNM: Tumor Node Metastasis.