HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation

Table 5 Comparison of the frequencies of human leukocyte antigen-B alleles in the acute cellular rejection group (n = 23) and the non-acute cellular rejection group (n = 76) in the non-primary sclerosing cholangitis population

HLA-B	Acute rejection		Non acute rejection		OR	95%CI	Uncorrected
allele	n (alleles)	(%)	n (alleles)	(%)			P value
*05	0	(0)	4	(2.6)	0.3	0.1-2.9	0.34
*07	6	(13.0)	15	(9.9)	1.4	0.5-3.1	0.54
*08	12	(26.0)	20	(13.2)	2.1	0.8-4.6	0.04
*12	9	(19.6)	20	(13.2)	1.6	0.6-3.4	0.36
*13	1	(2.2)	4	(2.6)	1.0	0.2-5.4	0.67
*14	2	(4.3)	4	(2.6)	1.8	0.5-5.81	0.43
*15	5	(10.9)	21	(13.8)	0.8	0.3-2.1	0.51
*16	1	(2.2)	3	(2.6)	1.0	0.2-5.34	1.00
*17	0	(0)	4	(2.6)	0.3	0.1-2.9	0.63
*18	1	(2.2)	6	(3.9)	0.6	0.1-2.0	1.00
*21	0	(0)	2	(1.3)	0.7	0.1-2.5	1.00
*22	0	(0)	2	(1.3)	0.7	0.11-2.5	0.71
*27	2	(4.3)	7	(4.6)	1.0	0.3-4.0	1.00
*35	4	(8.7)	15	(9.9)	0.8	0.3-2.5	1.00
*37	2	(4.3)	3	(1.9)	2.4	0.4-10.3	0.34
*40	2	(4.3)	17	(11.2)	0.4	0.1-1.4	0.25
*41	1	(2.2)	2	(1.3)	1.9	0.3-11.3	0.56
*47	0	(0)	1	(0.7)	1.0	0.1-11.4	1.00

OR and corresponding 95%CIs were calculated using Woolf’s formula with Haldane’s correction. Uncorrected P value is calculated by the χ² test or the Fisher’s exact test where appropriate. HLA: Human leukocyte antigen.