HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation

Table 12 Killer immunoglobuline-like receptor gene copy number of the recipient and acute cellular rejection after liver transplantation

KIR gene	AR	Non-AR	P value
	mean copy number (95% CI)	mean copy number (95%CI)
KIR2DL1	1.69 (1.54-1.84)	1.64 (1.53-1.76)	0.64
KIR2DL2	0.52 (0.34-0.71)	0.53 (0.40-0.65)	0.97
KIR 2DL3	1.50 (1.30-1.70)	1.45 (1.33-1.58)	0.69
KIR 2DL4	2.10 (2.00-2.19)	1.98 (1.91-2.05)	0.06
KIR 2DL5	0.50 (0.27-0.73)	0.63 (0.49-0.78)	0.32
KIR 2DP1	1.71 (1.57-1.86)	1.70 (1.59-1.81)	0.89
KIR 2DS1	0.26 (0.12-0.40)	0.43 (0.33-0.54)	0.08
KIR 2DS2	0.62 (0.30-0.43)	0.54 (0.41-0.66)	0.56
KIR 2DS3	0.29 (0.13-0.44)	0.32 (0.20-0.40)	0.77
KIR 2DS4DEL1	1.17 (1.01-1.32)	1.08 (0.94-1.21)	0.45
KIR 2DS4WT2	0.55 (0.36-0.73)	0.48 (0.37-0.59)	0.53
KIR 2DS4TOT3	1.74 (1.60-1.88)	1.56 (1.45-1.67)	0.06
KIR 2DS5	0.21 (0.08-0.35)	0.32 (0.22-0.42)	0.25
KIR 3DL1E44	1.74 (1.60-1.88)	1.57 (1.46-1.67)	0.08
KIR 3DL1E95	1.74 (1.60-1.88)	1.56 (1.46-1.67)	0.06
KIR 3DL2	-	-	-
KIR 3DL3	-	-	-
KIR 3DP1	-	-	-
KIR 3DS1	0.33 (0.30-0.51)	0.40 (0.30-0.51)	0.47

The various KIR genes genotyped are listed in the leftmost column. Genes with S in the name (e.g., KIR2DS4) encode activating KIRs, genes with L in the name (e.g., KIR3DL1) encode inhibiting KIRs and genes with a P in its name (e.g., KIR3DP1) are pseudogenes. Statistical comparison was performed using the independent sample t test.

¹2DS4DEL refers to the 22-bp deletion variant of 2DS4;

²2DS4WT refers to the full-length form of the gene;

³2DS4TOT refers to the total number of 2DS4, i.e., 2DS4DEL and 2DS4WT combined; ^4,53DL1E4 and 3DL1E9 refers to exon 4 and 9 of the 3DL1 gene respectively. KIR: Killer immunoglobulin-like receptor; AR: Acute cellular rejection.