HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation

Table 11 Data on the relationship between killer immunoglobulin-like receptor gene phenotype in the recipient and the risk of acute cellular rejection after liver transplantation in patients with primary sclerosing cholangitis compared with patients without primary sclerosing cholangitis

Recipient KIR gene phenotype	Incidence of AR	P value
2DL1
(PSC)		-
Negative (n = 0)	-
Positive (n = 4)	40%
(other)		1.00
Negative (n = 3)	0%
Positive (n = 96)	25%
2DL2
(PSC)		0.37
Negative (n = 23)	33%
Positive (n =21)	48%
(other)		0.71
Negative (n = 54)	26%
Positive (n = 45)	22%
2DL3
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		1.00
Negative (n = 10)	20%
Positive (n = 89)	24%
2DL4
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		-
Negative (n = 0)	-
Positive (n = 99)	24%
2DL5
(PSC)		0.17
Negative (n = 28)	48%
Positive (n = 16)	25%
(other)		0.81
Negative (n = 51)	25%
Positive (n = 48)	22%
2DP1
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		1.00
Negative (n = 3)	0%
Positive (n = 96)	25%
2DS1
(PSC)		0.14
Negative (n = 13)	26%
Positive (n = 31)	20%
(other)		0.51
Negative (n = 60)	26%
Positive (n = 39)	20%
2DS2
(PSC)		0.37
Negative (n = 23)	33%
Positive (n = 21)	48%
(other)		0.48
Negative (n = 54)	26%
Positive (n = 45)	20%
2DS3
(PSC)		0.78
Negative (n = 34)	41%
Positive (n = 11)	36%
(other)		0.57
Negative (n = 76)	22%
Positive (n = 25)	28%
2DS4DEL1
(PSC)		0.11
Negative (n = 8)	38%
Positive (n = 36)	43%
(other)		0.10
Negative (n = 15)	7%
Positive (n = 85)	27%
2DS4WT2
(PSC)		0.81
Negative (n = 21)	38%
Positive (n = 23)	42%
(other)		0.71
Negative (n = 56)	22%
Positive (n = 43)	26%
2DS4TOTA3
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		1.00
Negative (n = 3)	0%
Positive (n = 96)	25%
2DS5
(PSC)		0.46
Negative (n = 34)	43%
Positive (n = 10)	30%
(other)		0.56
Negative (n = 69)	25%
Positive (n = 30)	20%
3DL1E44
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		-
Negative (n = 0)	-
Positive (n = 99)	25%
3DL1E95
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		1.00
Negative (n = 3)	0%
Positive (n = 96)	25%
3DL2
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		-
Negative (n = 0)	-
Positive (n = 98)	24%
3DL3
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		-
Negative (n = 0)	-
Positive (n = 99)	24%
3DP1
(PSC)		-
Negative (n = 0)	-
Positive (n = 44)	40%
(other)		-
Negative (n = 0)	-
Positive (n = 99)	24%
3DS1
(PSC)		0.42
Negative (n = 31)	44%
Positive (n =13)	31%
(other)		0.81
Negative (n = 61)	25%
Positive (n = 40)	23%

¹2DS4DEL refers to the 22-bp deletion variant of 2DS4;

²2DS4WT refers to the full-length form of the gene;

³2DS4TOT refers to the total number of 2DS4, e.g., 2DS4DEL and 2DS4WT combined; ^4,53DL1E4 and 3DL1E9 refers to exon 4 and 9 of the 3DL1 gene respectively. The various KIR genes genotyped are listed in the leftmost column. Genes with S in the name (e.g., KIR2DS4) encode activating KIRs, genes with L in the name (e.g., KIR3DL1) encode inhibiting KIRs and genes with a P in the name (e.g., KIR3DP1) are pseudogenes. Uncorrected P value was calculated by the χ² test or the Fisher’s exact test where appropriate. KIR: Killer immunoglobulin-like receptor; AR: Acute cellular rejection; PSC: Primary sclerosing cholangitis.