HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation

Table 10 Data on the relationship between killer immunoglobulin-like receptor gene phenotype (presence/absence of gene) in the recipient and the risk of acute cellular rejection after liver transplantation in the total patient population

Recipient KIR gene phenotype		Incidence of AR	P value
2DL1	Negative (n = 3)	0%	0.37
	Positive (n = 140)	29%
2DL2	Negative (n = 79)	28%	0.92
	Positive (n = 64)	29%
2DL3	Negative (n = 10)	20%	0.44
	Positive (n = 133)	28%
2DL4	Negative (n = 0)	-	-
	Positive (n = 143)	29%
2DL5	Negative (n = 79)	32%	0.27
	Positive (n = 64)	24%
2DP1	Negative (n = 3)	0%	0.54
	Positive (n = 140)	31%
2DS1	Negative (n = 91)	32%	0.24
	Positive (n = 52)	20%
2DS2	Negative (n = 76)	27%	0.85
	Positive (n = 67)	29%
2DS3	Negative (n = 108)	28%	0.79
	Positive (n = 35)	31%
2DS4DEL1	Negative (n = 23)	9%	0.03
	Positive (n = 120)	31%
2DS4WT2	Negative (n = 77)	27%	0.84
	Positive (n = 66)	29%
2DS4TOTA3	Negative (n = 3)	0%	0.67
	Positive (n = 140)	29%
2DS5	Negative (n = 104)	32%	0.47
	Positive (n = 39)	24%
3DL1E44	Negative (n = 3)	0%	0.61
	Positive (n = 140)	29%
3DL1E95	Negative (n = 3)	0%	0.62
	Positive (n = 140)	28%
3DL2	Negative (n = 0)	-	-
	Positive (n = 143)	29%
3DL3	Negative (n = 0)	-	-
	Positive (n = 143)	29%
3DP1	Negative (n = 0)	-	-
	Positive (n = 143)	29%
3DS1	Negative (n = 91)	31%	0.39
	Positive (n = 52)	25%

¹2DS4DEL refers to the 22-bp deletion variant of 2DS4;

²2DS4WT refers to the full-length form of the gene;

³2DS4TOT refers to the total number of 2DS4, i.e., 2DS4DEL and 2DS4WT combined; ^4,53DL1E4 and 3DL1E9 refers to exon 4 and 9 of the 3DL1 gene respectively. The various KIR genes genotyped are listed in the leftmost column. Genes with S in the name (e.g., KIR2DS4) encode activating KIRs, genes with L in the name (e.g., KIR3DL1) encode inhibiting KIRs and genes with a P in the name (e.g., KIR3DP1) are pseudogenes. Uncorrected P value is calculated by the χ² test or the Fisher’s exact test where appropriate. KIR: Killer immunoglobulin-like receptor; AR: Acute cellular rejection.