Extent of lymphadenectomy and perioperative therapies: Two open issues in gastric cancer

doi:10.3748/wjg.v20.i14.3889

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2014; 20(14): 3889-3904
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3889

Table 4 Main data regarding adjuvant chemoradiotherapy for gastric cancer

Ref.	Study design	No. of patients	Survival (P value)	Disease free survival (P value)	Recurrence (P value)	Loco-regional recurrence (P value)
Moertel et al[44], 1984	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 39	At 5 yr	At 5 yr	-	S vs SCRT
		SCRT: 23	S < SCRT	S < SCRT		(NS)
		SCRT: 23	(0.05)	(0.02)
Allum et al[45], 1989 BSCG	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SCT)	S: 145	At 5 yr	-	-	S vs SCRT (NS)
		SCRT: 153	S vs SCRT			S vs SCT (NS)
		SCT: 138	vs CT (NS)
Hallissey et al[46], 1994 BSCG	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SCT)	S: 145	At 5 yr	-	-	-
		SCRT: 153	S vs SCRT
		SCT: 138	vs CT (NS)
Macdonald et al[42], 2001INT-0116	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 275	At 3 yr	At 3 yr	At 3 yr	At 3 yr
		SCRT: 281	S < SCRT	S < SCRT	S > SCRT	S > SCRT
		SCRT: 281	(0.005)	(0.001)	(0.001)	(0.0001)
Dikken et al[49], 2010	Retrospective surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 694	At 24 mo S vs SCRT (NS)	At 24 mo	-	At 24 mo
Dikken et al[49], 2010		SCRT: 91	At 24 mo S vs SCRT (NS)	S vs SCRT (NS)	-	S > SCRT (0.0015)
Kim et al[51], 2005	Observational surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 446	At 5 yr	At 5 yr	-	At 5 yr
		SCRT: 544	S < SCRT	S < SCRT		S > SCRT
		SCRT: 544	(0.01)	(0.01)		(0.005)
Smalley et al[53], 2012	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 227	At 10 yr	At 10 yr	At 10 yr	Ar 10 yr
INT-0116		SCRT: 282	S < SCRT	S < SCRT	S > SCRT	S > SCRT
INT-0116		SCRT: 282	(0.0046)	(0.001)	(0.006)	(0.0001)
Fiorica et al[54], 2007	Meta-analysis surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 424	At 5 yr	-	-	-
		SCRT: 444	S < SCRt
		SCRT: 444	(0.00001)
Lee et al[55], 2011	RCT surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SC)	SCRT: 230	-	At 3 yr	SCRT vs SC (NS)	SCRT vs SC (NS)
Lee et al[55], 2011		SC: 228	-	SCRT vs SC (NS)	SCRT vs SC (NS)	SCRT vs SC (NS)

RCT: Randomized controlled trial; NS: Not significant.

Citation: Giuliani A, Miccini M, Basso L. Extent of lymphadenectomy and perioperative therapies: Two open issues in gastric cancer. World J Gastroenterol 2014; 20(14): 3889-3904
URL: https://www.wjgnet.com/1007-9327/full/v20/i14/3889.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i14.3889