Computational biology approach to uncover hepatitis C virus helicase operation

Figure 2 Cyclic ligand-induced conformational motions in hepatitis C virus helicase. Top row: binding of the substrate ligand led to switching from open to closed conformation. Release of the product ligand induced motions back to the open form; Bottom row: motions of the motor domains relative to the nucleic acid binding cleft that are critical for grip control are indicated by arrows.