Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population

Table 4 Clinical characteristics of apolipoprotein C3 wild-type homozygotes (rs2854117 C/C and rs2854116 T/T) and carriers of one or more variant alleles (rs2854117 T and rs2854116 C) in the study population

Characteristic	Overall series			NAFLD patients			Controls
	Noncarriers	Carriers	P value	Noncarriers	Carriers	P value	Noncarriers	Carriers	P value
n	197	602		96	294		101	308
Female/male	110/87	306/296	0.250	48/48	157/137	0.638	62/39	149/159	0.903
Age (yr)	47.95 ± 16.86	48.95 ± 15.76	0.447	49.16 ± 17.23	49.96 ± 15.83	0.672	46.80 ± 16.51	47.98 ± 15.65	0.516
BMI (kg/m2)	23.69 ± 4.08	23.42 ± 3.73	0.387	25.21 ± 2.48	24.70 ± 2.91	0.123	22.14 ± 4.07	22.19 ± 4.10	0.910
Waist (cm)	78.97 ± 9.56	80.17 ± 9.66	0.130	85.36 ± 7.11	83.79 ± 8.49	0.074	72.90 ± 7.40	76.72 ± 9.45	0.000
ALT (U/L)	39.47 ± 34.79	39.46 ± 31.98	0.999	48.60 ± 44.85	43.64 ± 38.51	0.294	30.79 ± 17.50	35.48 ± 23.54	0.066
AST (U/L)	32.71 ± 36.37	33.08 ± 37.72	0.904	36.35 ± 42.00	32.44 ± 37.14	0.386	29.25 ± 29.86	33.70 ± 38.31	0.287
FPG (U/L)	5.46 ± 1.26	5.63 ± 1.49	0.135	5.82 ± 1.46	6.09 ± 1.86	0.201	5.12 ± 0.91	5.20 ± 0.79	0.435
TG (mmol/L)	2.67 ± 1.68	2.54 ± 1.47	0.341	2.88 ± 1.29	2.92 ± 1.48	0.840	2.46 ± 1.97	2.20 ± 1.39	0.134
TC (mmol/L)	4.97 ± 0.98	4.96 ± 0.94	0.887	5.18 ± 0.96	5.17 ± 1.01	0.903	4.77 ± 0.96	4.76 ± 0.81	0.935
HDL (mmol/L)	2.25 ± 2.21	1.99 ± 1.72	0.134	1.51 ± 0.46	1.78 ± 1.10	0.001	2.96 ± 2.89	2.19 ± 2.14	0.015
LDL (mmol/L)	3.84 ± 3.09	3.68 ± 2.66	0.477	4.43 ± 3.71	4.24 ± 3.35	0.659	3.28 ± 2.24	3.14 ± 1.61	0.564
FINS (μU/mL )	5.83 ± 1.20	5.90 ± 1.24	0.545	6.22 ± 1.24	6.28 ± 1.36	0.712	5.46 ± 1.03	5.53 ± 1.00	0.554
HOMA-IR (U)	1.42 ± 0.43	1.48 ± 0.52	0.111	1.62 ± 0.57	1.69 ± 0.61	0.309	1.25 ± 0.34	1.28 ± 0.31	0.376
APOC3 (mg/dL)	13.94 ± 2.01 (n = 34)	14.38 ± 1.92 (n = 146)	0.231	13.60 ± 1.90 (n = 19)	14.37 ± 1.98 (n = 80)	0.231	15.22 ± 1.79 (n = 15)	14.20 ± 1.89 (n = 66)	0.059

Data are shown as mean ± SD. Statistically significant differences were tested using the Student’s unpaired t test or by χ² test when appropriate. A P value < 0.05 was considered significant. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyltransferase; FPG: Fasting blood glucose; UA: uric Acid; TC: Total cholesterol; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; FINS: Fasting blood insulin; NAFLD: Nonalcoholic fatty liver disease; TG: Triglyceride; HOMA-IR: Homeostatic model assessment of insulin resistance; BMI: Body mass index.