Prognostic value of number of examined lymph nodes in patients with node-negative gastric cancer

Table 3 Univariate and multivariate survival analyses of 497 node-negative gastric cancer patients

Variables	5-YSR	Univariate analysis		Multivariate analysis
		χ2	P value	HR (95%CI)	P value
Gender		1.213	0.271
Male	66.0
Female	70.4
Age at surgery (yr)		2.720	0.099
≤ 60	70.1
> 60	64.2
Tumor size (cm)		3.548	0.060
≤ 4	71.0
> 4	63.2
Tumor location		0.167	0.682
Upper	69.9
Middle	53.2
Lower	69.5
Diffuse	60.4
Type of gastrectomy		2.045	0.153
Subtotal	68.3
Total	61.4
Histological type		0.117	0.732
Undifferentiated	67.9
Differentiated	66.2
Extent of lymphadenectomy		6.093	0.014
Limited	63
Extended	73.2
Extent of examined lymph nodes (LNs)		12.112	0.001
Perigastric	58.9
Extragastric	73.3
Depth of invasion		22.355	< 0.001		< 0.001
T1	88.2			1
T2	79.8			1.801 (0.613-5.293)	0.285
T3	74.6			2.102 (0.703-6.287)	0.184
T4	59.1			4.066 (1.502-11.007)	0.006
Number of examined LNs		32.690	< 0.001	0.334 (0.221-0.506)	< 0.001
≤ 15	58.6			1
> 15	84.3			0.327 (0.216-0.495)	< 0.001
TNM Classification 7th		22.541	< 0.001
Ia	88.2
Ib	79.8
IIa	74.6
IIb	59.3
IIIb	53.8

5-YSR: 5-year survival rate; TNM: Tumour, node, metastasis.