Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

Table 4 Clinicopathological features of primary biliary cirrhosis based on the predominant immunoglobulin class of the plasma cell

No. of cases(female:male)	Group A28 (25:3)	Group B12 (10:2)	P value
Age (yr)	56.1 ± 14.5 (56)	66.0 ± 7.2 (66)	0.0479
Laboratory data
AST (IU/L)	50.5 ± 31.2 (43.5)	55.0 ± 28.3 (42.5)	0.5839
ALT (IU/L)	54.2 ± 43.6 (45.5)	55.0 ± 35.4 (46.5)	0.7238
ALP (IU/L)	681.7 ± 655.0 (446)	389.1 ± 136.3 (358.5)	0.4166
IgG (mg/dL)	1737.4 ± 510.4 (1600)	2081.3 ± 784.4 (2062.5)	0.2658
IgM (mg/dL)	340.78 ± 219.0 (280.5)	197.3 ± 198.7 (133.5)	0.0077
IgA (mg/dL)	309.2 ± 129.8 (281)	304.6 ± 107.0 (268.5)	0.8184
AMA, M2 (positive ratio)	80.10%	55.60%	0.1916
ANA (positive ratio)	65.40%	80.00%	0.6880
Histological findings (scores)
Interface hepatitis1	2.4 ± 0.6 (2)	2.8 ± 0.6 (3)	0.0688
Lobular hepatitis2	2.3 ± 0.6 (2)	2.3 ± 0.6 (2)	0.8577
Infiltration of mononuclear cells positive for (scores)
CD3 at the interface3	2.7 ± 1.2 (2.5)	2.8 ± 1.3 (3)	0.7039
CD38 at the interface3	2.4 ± 1.5 (2)	3.3 ± 1.3 (4)	0.0205
CD3 in the hepatic lobules3	2.1 ± 0.8 (2)	2.4 ± 1.2 (2)	0.5341
CD38 in the hepatic lobules3	0.9 ± 0.9 (1)	1.6 ± 1.1 (2)	0.0497

¹The score was graded from 2 to 4 for each case;

²the score was graded from 0 to 4 for each case;

³ The score was graded from 0 to 6 for each case. Group A, IgM-predominant cases and IgM/IgG-equal cases; group B, IgG-predominant cases. Age, laboratory data expect autoantibodies and scores are shown as the mean ± SD and (median); anti-mitochondrial antibodies (AMA)(+) ≥ 40; M2(+) ≥ 5; antinuclear antibodies (ANA)(+) ≥ 40. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase.