Thiopurine-methyltransferase variants in inflammatory bowel disease: Prevalence and toxicity in Brazilian patients

Table 4 Analysis of thiopurine-methyl-transferase gene polymorphisms in patients with inflammatory bowel disease n (%)

TPMT SNP	CHz	HTz	RHz	P-value
C238G	C:C	C:G	G:G
CD (n = 143)	137 (95.8)	6 (4.2)	0	0.722
UC (n = 71)	69 (97.2)	2 (2.8)	0
G460A/A719G	G:G/A:A	G:A/A:G	A/A:G/G
CD (n = 126)	118 (93.7)	8 (6.3)	0	0.750
UC (n = 69)	66 (95.7)	3 (4.3)	0
A719G	A:A	A:G	G:G
CD (n = 135)	122 (90.4)	13 (9.6)	0	0.612
UC (n = 71)	66 (93.0)	5 (7.0)	0

Data were analyzed using Fisher’s exact test. CHz: Common homozygous; HTz: Heterozygous; RHz: Rare homozygous. CD: Crohn’s disease; UC: Ulcerative colitis; TPMT: Thiopurine-methyl-transferase.