Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

Figure 5 Effects of drugs on indomethacin-induced vascular permeability and oxidative stress. Animals were given indomethacin (10 mg/kg, po) and killed 24 h later. AL-Na (250 and 500 mg/kg) or Reb (100 mg/kg) was given orally twice at 30 min before and 6 h after administration of indomethacin. A Vascular permeability; B: Superdismdeoxidase content; C: Glutathione peroxidase activity; D: Catalase activity were measured. Each column and vertical bar represents the mean ± SE (n = 8). Significantly different from the control group at ^aP < 0.05 and ^bP < 0.01 (Student’s t-test); Significantly different from the indomethacin group at ^cP < 0.05 and ^dP < 0.01, respectively (Dunnett’s test). Cont: Control; IND: Indomethacin; AL-Na: Sodium alginate; Reb: Rebamipide.