Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma

Table 3 Univariate and multivariate analyses of survival

Clinicopathological factor		DFS			OS
		Univariate	Multivariate	Multivariate P value	Univariate	Multivariate	Multivariate P value
		HR (95%CI)	HR (95%CI)		HR (95%CI)	HR (95%CI)
Sex	Women	Reference			Reference
	Men	0.89 (0.63-1.26)			1.00 (0.67-1.51)
Age (yr)	≥ 70	Reference			Reference
	< 70	0.87 (0.59-1.30)			0.65 (0.42-1.0)
Performance status	≥ 90	Reference			Reference
	≥ 80	2.64 (0.84-8.34)			1.84 (0.45-7.47)
Tumor location	Distal	Reference			Reference		0.099
	Proximal	1.22 (0.88-1.70)			1.51 (1.02-2.24)	1.40 (0.94-2.09)
Differentiation	Low	Reference			Reference
	Moderate	0.81 (0.56-1.19)			0.78 (0.50-1.21)
	High	0.20 (0.03-1.47)			0.31 (0.04-2.27)
Gloss type	Protrusion	Reference		0.081	Reference		0.008
	Ulcer	0.81 (0.58-1.14)	0.83 (0.59-1.18)	0.301	0.70 (0.47-1.03)	0.69 (0.46-1.03)	0.072
	infiltration	2.31 (1.05-5.07)	1.94 (0.86-4.37)	0.108	2.56 (1.15-5.69)	2.19 (0.95-5.05)	0.066
Tumor size	< 5 cm	Reference		0.363	Reference		0.099
	≥ 5 cm	1.45 (1.04-2.01)	1.17 (0.84-1.63)		1.67 (1.15-2.43)	1.40 (0.94-2.09)
Preoperative serum CEA	≥ median	Reference			Reference
	< median	0.94 (0.68-1.31)			0.84 (0.58-1.23)
Preoperative serum CA19-9	≥ median	Reference			Reference
	< median	0.84 (0.575-1.24)			0.85 (0.54-1.34)
CEA tumor status	+	Reference			Reference
	-	1.00 (0.59-1.68)			0.45 (0.20-1.03)
P53 tumor status	+	Reference			Reference
	-	1.40 (0.98-2.01)			1.12 (0.72-1.75)
AJCC stage (7th)	III	Reference		0	Reference		0.000
	II	0.36 (0.24-0.53)	0.63 (0.51-0.77)		0.32 (0.20-0.51)	0.59 (0.46-0.75)
Radical surgery	R1	Reference		0.006	Reference		0.214
	R0	0.34 (0.19-0.60)	0.43 (0.23-0.78)		0.45 (0.23-0.86)	0.65 (0.33-1.28)
Adjuvant chemotherapy	Yes	Reference		0.008	Reference		0.000
	No	1.58 (1.15-2.17)	1.55 (1.12-2.14)		1.99 (1.38-2.87)	2.01 (1.37-2.94)
First-line chemotherapy	Yes				Reference		0.013
	No				1.87 (1.14-3.07)	1.95 (1.15-3.30)

CEA: Carcinoembryonic antigen; OS: Overall survival; DFS: Disease-free survival.