Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome

Table 4 The correlation of hMSH2, hMLH1, TGFβRII, E-cadherin, β-catenin, matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-2 expression in Lynch syndrome

Lynch syndrome		hMSH2			hMLH1			TGFβRII			E-cadherin		Cytomembraneβ-catenin		Cytoplasmicβ-catenin		MMP-7
		(++)	(+)	(-)	(++)	(+)	(-)	(++)	(+)	(-)	(+)	(-)	(+)	(-)	(+)	(-)	(++)	(+)	(-)
hMLH1	(++)	0	7	0
	(+)	0	0	9
	(-)	0	0	14
TGFβRII	(++)	0	2	2	0	0	4
	(+)	0	4	4	0	0	8
	(-)	0	1	17	7	9	2
E-cadherin	(+)	0	7	19	6	7	13	3	7	16
	(-)	0	0	4	1	2	1	1	1	2
Cytomembrane β-catenin	(+)	0	5	20	4	8	13	3	6	16	21	4
	(-)	0	2	3	3	1	1	1	2	2	5	0
Cytoplasmic β-catenin	(+)	0	3	11	2	6	6	1	2	11	14	0	10	4
	(-)	0	4	12	5	3	8	3	6	7	12	4	15	1
MMP-7	(++)	0	2	1	2	0	1	1	2	0	1	2	1	2	2	1
	(+)	0	4	7	4	1	6	3	2	6	10	1	9	2	9	2
	(-)	0	1	15	1	8	7	0	4	12	15	1	15	1	3	13
TIMP-2	(++)	0	2	2	2	1	1	0	0	4	3	1	3	1	2	2	1	1	2
	(+)	0	2	13	2	8	5	0	4	11	13	2	13	2	8	7	1	6	8
	(-)	0	3	8	3	0	8	4	4	3	10	1	9	2	4	7	1	4	6