Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors

Table 3 Summary of medical treatments for patients with gastric neuroendocrine tumors

	Type I GNET	Type II GNET	Type III GNET	Type IV GNET
Resection	Simple surveillance, endoscopic polypectomy, surgical excision associated with or without surgical antrectomy, total gastrectomy	Simple surveillance, endoscopic polypectomy, surgical excision associated with or without surgical antrectomy, total gastrectomy	Radical surgery	Radical surgery
Chemotherapy				Combination chemotherapy:Etoposide + cisplatin (CDDP)/carboplatin octreotide and pasireotide (SOM230);Somatosatin analogues;
				CDDP + CPT-11117Lu- and 90Y-labelled somatostatin analogues;Selective internal radiation therapy
Targeted radio therapy
Biological therapy	Interferon-α
Molecular targeted therapy	Inhibition of angiogenesis or molecular targeting of growth factor receptors, including sunitinib and imatinib

GNET: Gastric neuroendocrine tumor.