Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors

Table 2 New tissue and serum tumor markers for specific diagnostics and prognostics of gastric neuroendocrine tumors

Ref.	Case	Hormones, amines and peptides for specific diagnostic and prognostics of GNETs	Expression
Giandomenico et al[42]	15	CD133	20% positive
Mia-Jan et al[43]	2	ISL1	Complete loss
Agaimy et al[44]	1	c-kit	Overexpression
Mori et al[45]	51	Cyclin E	Independent prognostic factor
		Cyclin E and P53	Prognostic relevance
Namikawa et al[41]	5	Chromogranin A	40% positive
		Synaptophysin	60% positive
		CD56	60% positive
		Neuron-specific enolase	40% positive
		p53 protein	100% positive

GNET: Gastric neuroendocrine tumor; ISL1: Islet-1.