Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2013; 19(8): 1173-1181
Published online Feb 28, 2013. doi: 10.3748/wjg.v19.i8.1173
Table 1 Clinical studies on histone deacetylase inhibitors for treatment of patients with pancreatic cancer
HDACIPatients total numberPatients with PC numberTime scheduleDosage schedule (HDACI)MTD (HDACI)Responses (for patients with pancreatic cancer treated with HDACI)Main toxicitiesRef.
PRSDPD
VPA + epirubicin phase I481q21 d15-160 mg/kg per day iv/po d1, d2140 mg/kg per day1--Neutropenia, thrombocyto-penia, hypocalcaemia, fatigue, QTc prolongation[33]
4-PB phase I211q28 d60-360 mg/kg iv 2 × daily d1-d5, d8-d12300 mg/kg per day--1Fatigue, headache, nausea, vomiting, confusion[36]
MS-275 + 13-cis retinoic acid phase INot defined1q28 d4-5 mg/m2po, once weekly5 mg/m2-1-Hyponatremia, neutropenia, anemia, fatigue[39]
MS-275 phase I271a: q14 d b: q28 d c: q28 d2-6 mg/m2po a: one dose 1st wk b: 2 × weekly for 3 wk c: 1 × weekly for 3 wka: 6 mg/m2 b: not defined c: 4 mg/m2--1Hypophospha-temia, hyponatremia, nausea, asthenia, fatigue, anorexia1[40]
CI-994 phase II1717Continues8 mg/m2 per day po--2N/DThrombocyto-penia, fatigue, anorexia, nausea, vomiting, bruising, hematuria[42]
CI-994 phase I531a: acute q21 d b: chronic q10 wka: 10-15 mg/m2 per day po d1-d14 b: 5-12.5 mg/m2 per day po d1-d56a: 15 mg/m2 b: 8 mg/m2--1Thrombocyto-penia, neutropenia, nausea, vomiting, diarrhea, fatigue, hoarseness, paresthesias, alopecia[43]
CI-994 + capecita-bine phase I544 sch. ca: q21 d b: q42 d c: q21 da: 4-10 mg/m2 per day po d1-d14 b: 6 mg/m2 per day po d1-d35 c: 4-8 mg/m2 per day po d1-d14a: 10 mg/m2 b: (abandoned) c: 8 mg/m2--4Thrombocyto-penia, anemia, anorexia, diarrhea, nausea, vomiting, fatigue[44]
CI-994 + carboplatin paclitaxel phase I302q21 d4-6 mg/m2 per day po d1-d14 or d1-d76 mg/m2 (d1-d7)--2Thrombocyto-penia, neutropenia, fatigue, alopecia, nausea[45]
CI-994 + gemcita-bine vs gemcita-bine alone phase II174174 (86 + 88)q28 d6 mg/m2 per day po d1-d21-8/68-60/68Thrombocyto-penia, neutropenia, anemia, nausea, vomiting, anorexia, diarrhea[46]
MGCD-0103 phase I382q21 d12.5-56 mg/m2 per day po d1, 3, 5, 8, 10, 1256 mg/m2 RPTD: 45 mg/m2--2Fatigue, anorexia, nausea, vomiting, diarrhea, abdominal pain, dehydration[48]
LAQ824 phase I393q21 d6-100 mg/m2 per day iv d1-d372 mg/m2 RPTD: < 72 mg/m2--3Thrombocyto-penia, fatigue, anorexia, nausea, vomiting, diarrhea, nonspecific ST-segment, hyperbiliru-binemia, transaminitis2[50]