Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

Table 7 Genetic polymorphism frequencies in patients with heavy iron loading (Grade 3 and 4) grouped according to no fibrosis (F0) vs advanced fibrosis (F3/F4)

Gene	No fibrosis (F0) (n = 103)		Advanced fibrosis (F3/4) (n = 60)		P value	Adjusted P value1
MCP1	AA 53/103	AG/GG	AA 28/60	AG/GG 32/60	0.555	0.433
	51.50%	50/103 48.5%	46.70%	53.3%
CCR2	GG 81/100	AG/AA	GG 50/59	AG/AA 9/59	0.549	0.277
	81%	19/100 19%	84.70%	15.3%
TGF β	GG 86/103	CG/CC 17/103	GG 51/60	CG/CC 9/60	0.800	0.968
	83.50%	16.5%	85%	15%
hOGG1	CC 54/102	CG/GG 48/102	CC 26/60	CG/GG 34/60	0.238	0.790
	52.90%	47.1%	43.30%	56.7%
IL10-1082	AA/AG 75/103	GG 28/103	AA/AG 43/60	GG 17/60	0.874	0.998
	72.8%	27.20%	71.80%	28.30%
IL10-592	AA/AC 34/103	CC 66/103	AA/AC 23/60	CC 37/60	0.492	0.659
	33.0%	67.0%	38.3%	61.7%
TLR4 299	AA 87/102	AG/GG 15/102	AA 54/59	AG/GG 5/59	0.248	0.848
	85.3%	14.7%	91.5%	8.5%
TLR4 399	CC 89/103	CT/TT 14/103	CC 53/59	CT/TT 6/59	0.524	0.985
	86.4%	13.6%	89.8%	10.2%

¹Adjusted for age:gender:alcohol consumption. MCP-1: Monocyte chemoattractant protein 1; CCR-2: Chemokine C-C motif receptor; IL10: Interleukin-10; TGF-β: Transforming growth factor-beta; TLR4: Toll-like receptor 4; hOGG1: Human 8-oxoguanine DNA glycosylase.