Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2013; 19(45): 8373-8381
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8373

Table 1 Rescue therapy strategies in drug resistance patients

DR patients	Rescue therapyprescriptions	HBN DNA after rescue therapy 12 w
DR patients	Rescue therapyprescriptions	< 500 copies/mL (n)	> 500 copies/mL (n)
LAM	+ ADV (n = 6)	4	2
(n = 11)	→ETV + ADV (n = 5)	3	2

ADV	+ ETV (n = 5)	4	1
(n = 12)	+ LAM (n = 7)	6	1

LDT	+ ADV (n = 6)	4	2
(n = 8)	→ETV + ADV (n = 2)	2	0

ETV	+ ADV (n = 2)	2	0
(n = 2)

LAM+ADV	→ ETV + ADV	1	1
(n = 2)	(n = 2)

LDT+ADV	→ ETV + ADV	1	0
(n = 1)	(n = 1)

+: Add-on; →: Altered drug. DR: Drug resistance; LAM: Lamivudine; ADV: Adefovir; LDT: Telbivudine; ETV: Entecavir; HBV: Hepatitis B virus.

Citation: Li L, Liu W, Chen YH, Fan CL, Dong PL, Wei FL, Li B, Chen DX, Ding HG. Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study. World J Gastroenterol 2013; 19(45): 8373-8381
URL: https://www.wjgnet.com/1007-9327/full/v19/i45/8373.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i45.8373

Li L, Liu W, Chen YH, Fan CL, Dong PL, Wei FL, Li B, Chen DX, Ding HG. Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study. World J Gastroenterol 2013; 19(45): 8373-8381 [PMID: 24363530 DOI: 10.3748/wjg.v19.i45.8373]

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