Decreased histone H2B monoubiquitination in malignant gastric carcinoma

Figure 3 Level of nuclear staining of uH2B according to Lauren classification of tumor type. A, B: Intestinal-type tumors showing (A) high-level staining (brown) of well-differentiated tumors and (B) fewer uH2B⁺ cells and moderate staining (yellow) of moderately-differentiated tumors; C, D: Diffuse-type tumors showing (C) low-level staining (light yellow) and few uH2B⁺ cells of poorly-differentiated tumors and (D) negative staining in poorly-differentiated tumors. Magnification: × 200.