Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy

Figure 3 Endoluminal ultrasonic biomicroscopy images. A: Show increase in tumor volume. Endoluminal ultrasonic biomicroscopy (eUBM) colon images acquired at the first (left) and second (right) time-points from azoxymethane (AOM)-dextran sulfate sodium (DSS)-treated mice. The volume of the pedunculated adenoma (Ad) increased between the first and second eUBM examinations; B: Show no alteration in tumor volume. eUBM colon images acquired at the first (left), second (middle) and third (right) time-points from AOM-DSS-treated mice. The lesion observed is a pedunculated tumor. Images show that the tumor volume is unchanged during the observation period; C: Show reduction in lesion size. eUBM colon images acquired at the first (a), second (b) and third (c) time-points from AOM-DSS-treated mice. The lesion observed at the first eUBM image is a mucosa hyperplasia (MH) with ulceration at the top. In the subsequent eUBM image, the MH has decreased, and a lymphoid infiltrate (LI) has appeared in the submucosa layer. In the third and last eUBM image, MH and LI have almost completely disappeared, which is confirmed by histological analysis (d, × 40 magnification). Mu: Mucosa; Sm: Submucosa.