Laparoscopic vs open total gastrectomy for gastric cancer: A meta-analysis

Table 1 Study characteristics

Author, year	Country	Study design	Group	No. of patients	Age(yr)	Gender(M/F)	BMI(kg/m2)	ASA (1:2:3)	Tumorsize (cm)	Tumor stage1	Extent of LND	Population
Dulucq et al[28], 2005	France	PCS	LTG	8	75 ± 8	3/5	NA	NA	5.5 ± 2	NA	D1 + β	EGC + AGC
			OTG	11	67 ± 14	5/6	NA	NA	6.1 ± 0.4	NA
Usui et al[9], 2005	Japan	RCS	LTG	20	66.0 ± 10.4	13/7	21.3 ± 3.1	NA	NA	8/10/2/0/0	D1 + β	EGC + AGC
			OTG	19	66.2 ± 10.2	14/5	22.1 ± 2.4	NA	NA	10/8/1/0/0
Kim et al[34], 2008	South Korea	RCS	LTG	27	57.3 ± 14.2	16/11	22.6 ± 3.1	NA	NA	NA	D1 + α/β, D2	EGC + AGC
			OTG	33	61.6 ± 9.2	23/10	22.4 ± 2.1	NA	NA	NA
Mochiki et al[15], 2008	Japan	RCS	LTG	20	66 ± 2.4	16/4	NA	NA	3.6 ± 0.5	NA	D1 + β	EGC
			OTG	18	63 ± 2.2	16/2	NA	NA	5.7 ± 0.8	NA
Topal et al[14], 2008	Belgium	PCS	LTG	38	68 (37-85)	23/15	24 (17-30)	NA	47 (7-180)	0/17/7/10/4	D2	EGC + AGC
			OTG	22	69 (38-86)	17/5	24 (17-30)	NA	30 (10-180)	0/7/7/6/2
Kawamura et al[30], 2009	Japan	RCS	LTG	46	64 ± 10.4	10/36	22.8 ± 3.0	15/27/4	NA	NA	D2	EGC
			OTG	35	65.2 ± 10.7	10/25	22.9 ± 2.4	14/15/6	NA	NA
Sakuramoto et al[16], 2009	Japan	RCS	LTG	30	63.7 ± 9.2	12/18	21.9 ± 2.7	9/20/1	4.0 ± 2.9	0/25/2/3/0	D1 + β, D2	EGC + AGC
			OTG	44	67.2 ± 9.9	10/34	22.5 ± 3.6	8/28/8	6.1 ± 3.7	0/15/17/12/0
Du et al[27], 2010	China	RCS	LTG	82	60.4 ± 18.5	54/28	22.3 ± 2.6	NA	5.4 ± 1.4	0/3/36/43/0	D2	AGC
			OTG	94	57.8 ± 17.2	61/33	22.5 ± 2.4	NA	5.9 ± 1.6	0/6/31/57/0
Kim et al[33], 2011	South Korea	RCS	LTG	63	55.9 ± 12.2	43/20	22.7 ± 2.5	45/15/3	3.8 ± 2.1	NA	D2	EGC
			OTG	127	57.3 ± 11.1	81/46	23.0 ± 2.9	86/39/2	3.9 ± 2.7	NA
Eom et al[10], 2012	South Korea	RCS	LTG	100	54.9 ± 13.5	57/43	22.7 ± 2.8	NA	4.3 ± 2.9	NA	D1 + β, D2	EGC + AGC
			OTG	348	58.7 ± 11.5	254/94	23.8 ± 2.9	NA	4.4 ± 3.0	NA
Guan et al[17], 2012	China	RCS	LTG	41	60.7 ± 9.1	33/8	NA	NA	NA	0/18/20/3/0	D2	EGC + AGC
			OTG	56	57.8 ± 9.9	40/16	NA	NA	NA	0/25/25/6/0
Siani et al[38], 2012	Italy	RCS	LTG	25	65 ± 8.5	15/10	NA	NA	NA	0/6/5/14/0	D1 + α/β, D2	EGC + AGC
			OTG	25	66 ± 7.8	18/7	NA	NA	NA	0/4/5/16/0
Kim et al[32], 2013	South Korea	RCS	LTG	139	58 (30-84)	86/53	23.6 (13.6-32.4)	85/46/8	3.2 (0.2, 15)	NA	D2	EGC + AGC
			OTG	207	56 (31-84)	134/73	24.1 (16.7-35.2)	137/52/18	4.0 (0.3, 22)	NA
Jeong et al[29], 2013	South Korea	RCS	LTG	122	63.2 ± 11.2	89/33	23.1 ± 3.4	33/80/9	NA	NA	D1 + β, D2	EGC + AGC
			OTG	122	62.6 ± 11.7	93/29	23.5 ± 3.2	43/67/12	NA	NA
Lee et al[37], 2013	South Korea	RCS	LTG	50	50.6 ± 22.1	32/18	23.2 ± 3.7	34/11/5	NA	0/24/13/9/4	D2	EGC + AGC
			OTG	50	51 ± 22.6	32/18	23 ± 3.4	31/16/3	NA	0/24/13/9/4

Continuous variables are presented as means ± SD or median and range.

¹Pathological tumor stage (0/I/II/III/IV). PCS: Prospective comparative study; RCS: Retrospective comparative study; LTG: Laparoscopic total gastrectomy; OTG: Open total gastrectomy; BMI: Body mass index; NA: Not available; ASA: American Society of Anesthesiologists; LND: Lymph node dissection; EGC: Early gastric cancer; AGC: Advanced gastric cancer; M/F: Male/female.