siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells

Table 2 Tumor volume changes in tumor-bearing mice (n = 6, mean ± SD)

	Subcutaneous tumor volume (mm3, mean ± SD)
Time	NS	G2	GH	FU	FU+G2	G2+FU+GH
Inoculation 5 d	7.72 ± 1.61	7.93 ± 1.74	8.11 ± 1.65	7.42 ± 1.51	6.51 ± 1.20	7.33 ± 1.32
Inoculation 8 d	20.19 ± 4.9123	13.44 ± 4.1213	33.28 ± 3.24123	17.51 ± 5.753	15.12 ± 5.013	15.44 ± 4.23
Inoculation 11 d	106.02 ± 6.6123	21.12 ± 4.0413	151.90 ± 8.31123	21.00 ± 5.0713	19.22 ± 4.3313	22.97 ± 4.95123
Inoculation 14 d	133.41 ± 6.4323	20.00 ± 4.7513	178.93 ± 3.11123	16.23 ± 6.5113	11.55 ± 4.11123	12.12 ± 3.11123
Inoculation 17 d	116.81 ± 0.6123	9.71 ± 3.8213	149.01 ± 3.02123	11.54 ± 2.4213	11.42 ± 1.1113	10.47 ± 1.0213

¹Compared with NS group, P < 0.05;

²Compared with G₂ group, P < 0.05;

³Compared with GH group, P < 0.05. NS: Normal saline; G₂: Recombinant plasmid; GH: Growth hormone; FU: 5-fluorouracil.