Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care

Table 2 Factors independently associated with severe Clostridium difficile infection among patients in medical intensive care unit

Variables	Unadjusted OR (95%CI)	P value	Adjusted OR (95%CI)	P value
Glasgow coma score	1.16 (0.99-1.36)	0.15	-
Diabetes mellitus	4.89 (1.00-23.93)	0.04	-
Previous PPI exposure	2.55 (0.67-9.66)	0.17	-
Coamoxiclav (in the previous 8 wk)	2.43 (0.65-9.07)	0.18	-
Fluoroquinolones (in the previous 8 wk)	6.0 (1.12-32.28)	0.026	9.29 (1.16-74.28)	0.036
C-reactive protein (mg/L; 10 mg/L increments)	1.10 (1.02-1.18)	0.014	1.11 (1.02-1.21)	0.021
Male gender	5.11 (0.95-27.55)	0.045	8.45 (1.06-67.16)	0.044

Exposure to fluoroqionolones, C-reactive protein level and gender were included in the multivariate model [The value of the likelihood was 34.56 with 3 df, and χ² test: 18.37 (P < 0.0001)]. OR: Odds ratios; PPI: Proton pump inhibitor.