Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir

Table 1 Baseline characteristics of patients n (%)

Variables	Total (n = 106)	LdT + ADV (n = 53)	LAM + ADV (n = 53)	P value
Mean age, yr	46.3 (22-76)	49.0 (23-76)	43.7 (22-73)	0.053
Male	79 (74.5)	42 (79.2)	37 (69.8)	0.265
Liver cirrhosis	24 (22.6)	13 (24.5)	11 (20.8)	0.647
Laboratory results
AST (IU/L)	29 (7-119)	33 (7-119)	28 (10-92)	0.125
ALT (IU/L)	28 (13-125)	26 (15-84)	29 (13-125)	0.098
Total bilirubin (mg/dL)	0.7 (0.3-1.8)	0.7 (0.3-1.8)	0.8 (0.3-1.6)	0.382
Albumin (g/dL)	4.5 (0.7-5.4)	4.4 (3.4-5.4)	4.6 (0.7-5.1)	0.777
Prothrombin time	1.01 (0.91-1.42)	1.00 (0.91-1.42)	1.02 (0.93-1.24)	0.917
Platelet count (× 109/L)	175 (45-293)	175 (67-290)	174 (45-293)	0.610
AFP (ng/mL)	2.87 (0.86-57.54)	2.61 (1.57-11.66)	2.98 (0.86-57.54)	0.030
Mean prior LAM period, mo (range)	32.2 (8-139)	31.5 (8-77)	33.5 (11-139)	0.695
Mean prior LAM + ADV period, mo (range)	17.1 (6-45)	18.3 (6-45)	14.9 (6-39)	0.131
YMDD mutation	106 (100)	53 (100)	53 (100.0)	-
rtM204I alone	27 (25.5)	13 (24.5)	14 (26.4)	0.643
rtM204I + rtM204V	1 (0.9)	1 (1.9)
rtM204I + rtL180M	28 (26.4)	15 (28.4)	13 (24.5)
rtM204V + rtL180M	28 (26.4)	12 (22.6)	16 (30.2)	0.501
rtM204I + rtM204V + rtL180M	22 (20.8)	12 (22.6)	10 (18.9)	0.514
eGFR (mL/min per 1.73 m2)	89.1 (56.1-131.6)	89.8 (59.8-131.6)	85.7 (56.1-123.3)	0.437
Serum HBV DNA (log10 IU/mL)				0.729
Mean (SD)	3.71 (1.46)	3.66 (1.65)	3.76 (1.25)
Median (range)	3.63 (1.32-8.10)	3.34 (1.32-8.10)	3.78 (1.41-5.94)

Data expressed as mean (SD), mean (range) or median (range). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LAM: Lamivudine; ADV: Adefovire; HBV: High hepatitis B virus; eGFR: Estimated glomerular filtration rate; LdT: Telbivudine.