Mucosal healing and deep remission: What does it mean?

Table 3 Proposal of the CBEHI classification to assess Crohn’s disease activity

Activity level	Definition	Code
Clinical activity	Remission: CDAI < 150	C0
	Active: CDAI ≥ 150	C1
Biochemical activity	CRP normal	B0 (CRP)
	Elevated CRP	B1 (CRP)
	Calprotectin < 200 μg/g	B0 (Calpro)
	Calprotectin ≥ 200 μg/g	B1 (Calpro)
Endoscopic activity	Remission: SES-CD < 4	E0
	Active: SES-CD ≥ 4	E1
Histologic activity	Inactive	H0
	Active	H1
Imaging	Inactive: no fistulas, no stenoses	I0
	Active: presence of either fistula and/or stenosis	I1

Example: A Crohn’s disease (CD) patient with C0B0 (CRP) E1H1I0 would have clinical and biochemical remission, but endoscopic and histologic activity.