C/EBP homologous protein deficiency aggravates acute pancreatitis and associated lung injury

Figure 2 Experimental acute pancreatitis in Chop^-/- mice. Acute pancreatitis was induced using cerulein (Cn) and lipopolysaccharide (LPS) in Chop^-/- (KO) and wild-type (WT) mice. Histological examination was performed 24 h after induction of acute pancreatitis. Representative histological changes in pancreatic sections stained with hematoxylin and eosin are shown. Scale bar = 100 μm. Pathological changes in the pancreas were scored. Data are presented as mean ± SEM (n = 4). The data are normally distributed. ^aP < 0.05 vs WT mice without pancreatitis; ^cP < 0.050 vs WT mice with pancreatitis.