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Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 7, 2013; 19(41): 7055-7061
Published online Nov 7, 2013. doi: 10.3748/wjg.v19.i41.7055
Table 3 IFNL3 polymorphisms and insulin resistance in chronic hepatitis C
Cohorts sizeStudy designHCV genotypeIFNL3 SNP% IRHOMA-IRResultsEthnicityRef.
434Multi-center, retrospectiveHCV-1 (n = 434)rs1297986050%> 3CC genotype associated with reduced IRCaucasians48
202ProspectiveHCV-1 (n = 181)rs1297986032.20% (65/202)≥ 3CC genotype associated with reduced IRCaucasians49
HCV-4 (n = 21)
328RetrospectiveHCV-1 (n = 328)rs809991750% (84/168) in TT genotype vs 69.7% (53/76) in TG/GG genotype≥ 2.45 in TT genotype vs≥ 1.55 in TG/GG genotypeNo differences in IFNL3 genotype distribution according to HOMA-IRJapanese57
240RetrospectiveHCV-1 (n = 188)rs1297986046% (89/193)≥ 2No differences in HOMA-IR levels according to IFNL3 genotypesCaucasians59
HCV-2 (n = 3)
HCV- (n = 30)
HCV-4 (n = 19)