Inflammatory bowel disease serology in Asia and the West

doi:10.3748/wjg.v19.i37.6207

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Oct 7, 2013 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2013; 19(37): 6207-6213
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6207

Table 2 Antibody positivity and titre according to geography, ethnicity and disease n (%)

	Australia					Hong Kong (all Asian)
	CD	UC		Healthy		CD	UC	Healthy	Relatives
	Caucasian	Caucasian	Asian	Caucasian	Asian	CD	UC	Healthy	Relatives
Total	9	10	10	10	9	12	12	10	8
Antibody positivity
gASCA	6 (67)^a^c	0 (0)	1 (10)	1 (10)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
ALCA	4 (44)^a	1 (10)	0 (0)	2 (20)	0 (0)	1 (8)	1 (8)	0 (0)	0 (0)
ACCA	2 (22)	1 (10)	0 (0)	2 (20)	3 (33)	1 (8)	1 (8)	1 (10)	0 (0)
AMCA	6 (67)^a	0 (0)	0 (0)	1 (10)	3 (33)	7 (58)^a	2 (17)	2 (20)	2 (25)
pANCA	0 (0)	7 (70)^e	5 (50)^e	0 (0)	1 (11)	3 (25)	4 (33)^e	0 (0)	0 (0)
No. of positive antibodies
At least 1	9 (100)^a^c	2 (20)	1 (10)	2 (20)	4 (44)	7 (58)^a	4 (33)	2 (20)	2 (25)
At least 2	6 (67)^a^c	0 (0)	0 (0)	2 (20)	2 (22)	2 (17)	0 (0)	1 (10)	0 (0)
Antibody/QSS titre median (range)
gASCA	59 (146)^a^c	10 (12)	9 (47)	17 (45)	8 (21)	9 (44)	2 (39)	11 (17)	5 (46)
ALCA	46 (79)^a	17 (86)	14 (38)	23 (77)	18 (34)	27 (69)^a	17 (82)	17 (18)	24 (25)
ACCA	50 (188)	39 (101)	43 (56)	60 (310)	76 (135)	50 (80)	37 (87)	46 (77)	34 (62)
AMCA	111 (154)^a	63 (47)	70 (60)	79 (59)	75 (116)	121 (459)^a	60 (272)	59 (145)	74 (94)
QSS	14 (5)^a	9 (6)	10 (6)	12 (8)	9 (10)	13 (10)^a	8 (7)	8 (10)	10 (9)

^aSignificantly higher than all non-Crohn's disease (CD) groups combined (P < 0.05);

^cSignificantly higher than Hong Kong Asian CD (P < 0.05);

^eSignificantly higher than all non-ulcerative colitis (UC) groups combined (P < 0.05). gASCA: Anti-Saccharomyces cerevisiae; ALCA: Anti-laminaribioside carbohydrate IgG antibodies; ACCA: Anti-chitobioside carbohydrate IgA antibodies; AMCA: Anti-mannobioside carbohydrate IgG antibodies; pANCA: Atypical perinuclear anti-neutrophil cytoplasmic antibody; QSS: Quartile sum score.

Citation: Prideaux L, Kamm MA, De Cruz P, van Langenberg DR, Ng SC, Dotan I. Inflammatory bowel disease serology in Asia and the West. World J Gastroenterol 2013; 19(37): 6207-6213
URL: https://www.wjgnet.com/1007-9327/full/v19/i37/6207.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i37.6207