Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer

Table 2 Univariate and multivariate survival analyses in 1299 gastric cancer patients

Factor	Univariate1	Multivariate2
	P value	HR	95%CI	P value
Sex
Male vs female	0.3121
Age (yr)
65 ≤vs < 65	0.0033
Location
U vs ML	0.0027
Macroscopic type
Type 1/2/3/4 vs Type 0-I/II/III	< 0.0001	3.760	2.012-7.013	< 0.0001
Tumor size (mm)
40 ≤vs < 40	< 0.0001	2.128	1.259-3.597	0.0048
Histological type
Undifferentiated vs Differentiated	0.014
pT categories
T2/3/4 vs T1	< 0.0001
Venous invasion
Positive vs Negative	< 0.0001	1.721	1.247-2.375	0.0010
Lymphatic invasion
Positive vs Negative	< 0.0001	2.793	1.656-4.717	0.0001
pN categories
Positive vs Negative	< 0.0001	2.513	1.614-3.951	< 0.0001
AFP
producing vs non producing	0.0018
Liver metastasis
Positive vs Negative	< 0.0001	3.152	2.116-4.558	< 0.0001

¹The Kaplan-Meier method, and significance was determined by the log-rank test;

²Multivariate survival analysis was performed using Cox’s proportional hazard model. AFP: α-fetoprotein.