Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study

Table 2 Serum antibodies, duodenal immunohistology and tTGA-A antibody deposits in the safety and efficacy phase for all patients

	Baseline						Safety phase						Efficacy phase
							2 wk gluten + AN-PEP						2 wk gluten + AN-PEP or placebo
	Serum				Biopsy		Tx	Serum				Biopsy	Tx	Serum				Biopsy
	IgA-tTG	IgA-AG	IgG-AG	IgA/G-DGP-tTG	Marsh	IgA-tTG deposits		IgA-tTG	IgA-AG	IgG-AG	IgA/G-DGP-tTG	Marsh		IgA-tTG	IgA-AG	IgG-AG	IgA/G-DGP-tTG	Marsh	IgA-tTG deposits
1	-	-	-	-	I	ND	A	-	-	-	-	0	P	-	-	-	-	I	0
2	-	+/-	-	-	0	0	A	-	+	-	-	I	P	-	++	+	-	IIIA	1-2
3	-	-	-	-	I	0	A	-	-	-	-	I	P	-	-	-	-	IIIA	1-2
4	+/-	-	-	+	I	1	A	-	-	-	+	0	P	+	-	-	++	I	2-3
5	-	-	-	-	0	ND	A	-	-	-	-	0	P	-	-	-	-	0	0
6	-	-	-	-	0	0	A	-	-	-	-	0	P	-	-	-	-	0	1
7	-	-	-	-	0	0	A	-	-	-	-	0	P	-	-	-	-	I	1-2
8	-	-	-	-	I	ND	A	-	-	-	-	II	A	-	-	-	-	I	0
9	-	-	-	-	0	3	A	-	-	-	-	I	A	-	+/-	-	+	I	1
10	-	-	-	-	0	ND	A	-	+/-	-	-	I	A	-	+/-	+	+	I	0
11	-	-	-	-	I	0	A	-	+	-	-	II	A	-	+/-	-	-	IIIA	1
12	-	-	-	-	I	ND	A	-	-	-	-	I	A	-	-	-	-	I	0
13	-	-	-	-	0	ND	A	-	-	-	-	0	A	-	-	-	-	0	0
14	-	-	-	-	0	ND	A	-	-	-	-	0	A	-	-	-	-	0	0
15	-	-	-	++	0	ND	A	-	-	-	++	II	E	-	-	-	++	IIIA	ND
16	-	-	-	-	0	ND	A	-	-	-	-	IIIA	E	-	-	-	-	0	ND

The serum EMA-A antibodies remained negative in all patients during the entire study. Mucosal tTGA-A deposits were graded from 0 to 3. Tx: Treatment; A: AN-PEP; P: Placebo; E: Excluded; IgA-tTG: Anti-tissue transglutaminase IgA antibodies; IgA-GA: Anti-gliadin IgA antibodies; IgG-GA: Anti-gliadin IgG antibodies; IgA/G-DGP-tTG: Anti-tissue transglutaminase and deamidated gliadin-derived peptide IgA and IgG antibodies; I-FABP: Intestinal fatty acid binding protein; ND: Not determined. -: Negative; +/-: Dubious; +: Weak positive; ++: Positive; +++: Strong positive.