Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome

Table 1 Prevalence of gastroesophageal reflux disease/functional heartburn in irritable bowel syndrome patients

IBS patients (n)	IBS criteria	Diagnostic investigations of IBS	GERD prevalence	FH prevalence	Diagnostic investigations of heartburn	Ref.
101	Manning	S, HE, Sg, BE, BT, UE, SBB, BC, LE	25%	Not evaluated	SQ	Svedlund et al[19]
25	Manning	S, Sg, SC, HE, BE	28% (daily)	Not evaluated	S, UE, OM, pH (wireless)	Smart et al[20]
			52% (weekly)
100	Manning	S, LE, HE, BE	30%	Not evaluated	SQ	Whorwell et al[21]
350	Modified manning	SQ	79%	Not evaluated	SQ	Jones et al[22]
546	Modified manning	Postal SQ	46.5%	Not evaluated	Postal SQ	Kennedy et al[23]1
146	Rome I	S, PE, AU, HE, UE or BE (patients older than 50 yr)	28%	Not evaluated	S, UE	Stanghellini et al[24]
68	Rome I	SQ	3%	Not evaluated	SQ	Hu et al[25]1
68	Rome I	Phone SQ	11%	Not evaluated	Phone SQ	Cheung et al[12]1
52	Rome I	S, SC, HE	38% (ERD)	Not evaluated	S, UE	Camacho et al[26]1
			42% (NERD)
76 (IBS-C)	Rome II	SQ	32.9%	Not evaluated	SQ	Talley et al[27]
45 (IBS-D)			40.9%
3880	Rome II	Phone SQ	21%	Not evaluated	Phone SQ	Hungin et al[28]
	Rome I
	Manning
662	Rome II	SQ	25%	Not evaluated	SQ	Si et al[29]
517	Rome II	SQ	40%	Not evaluated	SQ	Balboa et al[30]
95	Rome II	SQ	21%	Not evaluated	SQ	Lee et al[31]1
40	Rome II	SQ	20%	Not evaluated	SQ	Hori et al[32]1
164	Rome II	SQ	43%	Not evaluated	SQ	Johansson et al[33]
113	Rome II	SQ	49.6%	Not evaluated	SQ	Schmulson et al[34]
252	Rome III	Postal SQ	32.9%	Not evaluated	Postal SQ	Jung et al[10]1
1419	Rome III	SQ	63.6%	Not evaluated	S, UE	Yarandi et al[35]1
	Rome II
381	Rome III	SQ	16%	Not evaluated	SQ	Kaji et al[36]1
1336 (in 1996) 799 (in 2006)	Rome III	Postal SQ	60.5%-71.9%	Not evaluated	Postal SQ	Olafsdottir et al[37]
	Rome II
	Manning
381	Rome III	SQ	16%	Not evaluated	SQ	Fujiwara et al[38]1
46	Rome III	SQ	41.3%	59%	S, UE, OM22, MII-pH	Martinucci et al[39]12

¹Articles listed in both Tables;

²Abstract only (publication type).GERD: Gastroesophageal reflux disease; FH: Functional heartburn; IBS: Irritable bowel syndrome; S: Symptoms; SQ: Symptom questionnaire; PE: Physical examination; HE: Hematological examinations; BE: Barium enema; BC: Bacteriological culture; SC: Stool culture; BT: Lactose/lactulose breath test; AU: Abdominal ultrasonography; UE: Upper endoscopy; LE: Lower endoscopy; SBB: Small-bowel biopsies; Sg: Sigmoidoscopy; OM: Esophageal manometry; pH: pH-metry; MII-pH: pH impedance monitoring; ERD: Erosive reflux disease; NERD: Nonerosive reflux disease.