Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2013; 19(34): 5645-5650
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5645
Table 1 Potency at prespecified locations of compounded preparations of topical 2% diltiazem that lacked content uniformity
Percentage of label claim (prescription number, type of packaging)
Sample location11, jar2, jar4, jar10, jar11, jar14, jar19, jar20, jar25, jar26, jar27, jar28, jar32, tube33, tube
Location 1111.9%110.8%102.9%97.5%126.0%83.3%100.2%71.4%73.0%39.9%94.8%83.8%44.3%67.4%
Location 2108.7%114.2%95.7%98.0%117.8%73.1%99.3%20.9%58.7%74.2%68.9%66.5%15.1%83.4%
Location 3142.1%112.0%100.6%101.1%144.9%93.4%91.2%82.3%67.3%52.1%63.4%81.1%16.8%80.7%
Location 4149.1%145.5%99.8%100.9%117.1%72.4%99.9%81.8%64.9%76.1%57.7%82.9%33.8%87.9%
Location 5110.6%106.5%109.0%92.9%107.4%112.4%95.9%69.2%63.2%67.9%54.3%71.5%67.7%81.5%
Location 6106.7%99.9%97.1%90.9%116.1%161.1%97.3%81.3%59.5%65.8%51.5%65.4%29.4%79.3%
Location 7110.8%103.8%100.8%85.9%121.2%211.2%77.8%79.9%55.2%72.0%56.1%65.6%42.0%83.0%
Location 8111.7%107.8%231.7%89.2%120.6%220.8%91.0%82.1%57.6%70.6%52.8%65.6%29.4%90.7%
Mean119.0%112.6%117.2%94.6%121.4%128.5%94.1%71.1%62.4%64.8%62.4%72.8%34.8%81.7%
Relative SD14.0%12.5%39.6%6.0%9.0%46.9%8.0%29.4%9.4%19.2%22.9%11.5%48.5%8.5%