Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease

Table 1 Results of the liver function tests in cases of hypertransaminasemia related to glucosamine consumption

	1-yr prior to consumption	During consumption	1-yr after consumption
AST (UI/L) (normal < 40)
Case 1	25	182	71
Case 2	36	161	36
ALT (UI/L) (normal < 40)
Case 1	33	282	85
Case 2	53	162	37
GGT (UI/L) (normal < 40)
Case 1	32	150	77
Case 2	18	31	15
AP (U/L) (normal < 290)		229	219
Case 1	240	183	213
Case 2	144
Total bilirubin (mg/dL) (normal < 1.2)
Case 1	0.3	0.8	0.4
Case 2	0.8	0.9	0.9

The results of the two cases are compared with analyses performed 1-yr prior to and after the episode. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma Glutamyl transpeptidase; AP: Alkaline phosphatase.