DNA methylation in inflammatory bowel disease and beyond

Table 1 High throughput DNA methylome profiling in inflammatory bowel disease

Ref.	Disease	Tissue/cell	Array platform	Significant differential methylation	GWAS overlap
	Human patients
Lin et al[73]	UC and CD	Intestinal	Illumina goldengate	7 CpG sites	Not reported
Cooke et al[66]	UC and CD	Rectal	Illumina infinium human methylation 27	3604 (UC) and 472 (CD) loci	Yes
Lin et al[72]	UC and CD	B cell	Illumina goldengate	24 (UC) and 14 (CD) CpG sites	Not reported
Häsler et al[69]	UC	Intestinal	Illumina human methylation 27 and nimblegen custom 385K	61 loci	No
Nimmo et al[67]	CD	Whole blood	Illumina human methylation 27	1117 CpG sites	Yes
	Mouse
Kellermayer et al[59]	DSS colitis (postnatal day 30 vs day 90)	Colon	Custom array (Agilent)	271 intervals	Not reported
Kellermayer et al[58]	Tlr2-/-	Colon	Custom array (Agilent)	387 intervals	Not reported

UC: Ulcerative colitis; CD: Crohn’s disease; GWAS: Genome-wide association studies; DSS: Dextran sulfate sodium.