MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled

doi:10.3748/wjg.v19.i32.5212

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2013; 19(32): 5212-5226
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5212

Table 1 MicroRNAs with a role in hepatocellular carcinoma

miRNAs	Function	Outcomes
miR-22	Predicted to bind iron-bound transferrin receptor (TfR1)	Targets TfR1, DMT1 expression thereby inhibiting cell cycle progression and growth
miR-200a
miR-320
miR-200b	Targets ferritin heteropolymers (FtH1, FtL)	Decreased miR-200b linked with enhanced cancer aggressiveness via increased iron indices
miR-122	Targets HFE, hemojuvelin, BMPr1a, BMP/SMAD signalling, hepcidin	Control of systemic iron homeostasis. Decreased miR-122 corresponds to decreased HFE and hemojuvelin expression. This correlates with increased hepcidin expression

HCC: Hepatocellular carcinoma; miR/miRNA: MicroRNA; DMT: Divalent metal transporter; HFE: Human haemochromatosis; BMP: Bone morphogenetic protein; FtH: Ferritin heavy; FtL: Ferritin light.

Citation: Greene CM, Varley RB, Lawless MW. MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled. World J Gastroenterol 2013; 19(32): 5212-5226
URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5212.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5212