Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux

Figure 1 Effects of proton-pump inhibitor monotherapy and subsequent treatment with rikkunshito alone or rikkunshito plus proton-pump inhibitor on visual analog scale scores for globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux. Proton-pump inhibitor (PPI) monotherapy was delivered for at least 2 wk prior to the experiment. Each value represents the mean ± SD. ^aP < 0.05, significantly different from the visual analog scale (VAS) score at week 0 in each group (paired t test). No significant between-group differences were found at any time point.