Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease

Table 7 Genetic association between inflammatory bowel disease-phenotype and either newly discovered Claudin-2 promoter polymorphisms or a nonsynonymous coding polymorphisms in MORC4 was analyzed by performing case-control studies

	rs62605981 (CLDN2)		rs72466477 (CLDN2)		rs6622126 (MORC4)
	allelic OR (95%CI)	P value	allelic OR (95%CI)	P value	allelic OR(95%CI)	P value
IBD	1.11 (0.71-1.73)	0.659	1.23 (0.79-1.91)	0.350	1.24 (0.91-1.70)	0.179
CD	0.83 (0.49-1.41)	0.501	1.16 (0.68-2.00)	0.584	1.61 (1.08-2.41)	0.018
UC	1.24 (0.69-2.26)	0.463	1.19 (0.68-2.06)	0.543	0.903 (0.61-1.33)	0.606

Results were based on 166, 89 and 89 cases of inflammatory bowel disease (IBD), Crohn’s disease (CD) and Ulcerative colitis (UC), respectively, available from the Swedish families and 333 controls (Table 1). OR (and its associated 95%CI) and P values (based on log likelihood ratio chi-square statistics) were calculated for the C allele of rs62605981, the AT allele of rs72466477, and the G allele of rs6622126. CLDN: Claudin.