Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors

Table 4 Factors associated with the development of hepatocellular carcinoma, identified by comparing patients with sustained virological response by multivariate analysis using Cox proportional hazard regression method

F3 + 4 parameter	RR	95%CI	P value
Map-like distribution	1.687	0.404-7.053	0.4734
Atypical hepatocytes	20.748	1.335-322.530	0.0303

Multivariate analysis using the Cox proportional hazard regression method was applied to the parameters in each of the F stage groups. In the F0 + 1 + 2 group, none of the factors showed any significant correlation with the development of hepatocellular carcinoma (HCC). In the F3 + 4 group, map-like distribution (RR = 1.687, 95%CI: 0.404-7.053, P = 0.4734) was not found to have any correlation while the presence of atypical hepatocytes (RR = 20.748, 95%CI: 1.335-322.5, P = 0.0303) was shown to be significantly associated with HCC development.