Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review

Table 3 Comparison of positive rates of commonly-used key immunohistochemical stains in hepatocellular carcinoma, hepatoid adenocarcinoma, and common gastric adenocarcinoma

IHC stains	HCC1	HAC2	Common GAC34
AFP	8.2%-37%	92.1%	0%-0.8%
GPC-3	84%	100%	3.4%
Hep Par 1	73%-93%	38.1%	4%-47%
CK19	8.2%-15%	100%	83.6%-89.7%

IHC: Immunohistochemical; HCC: Hepatocellular carcinoma; HAC: Hepatoid adenocarcinoma; GAC: Gastric adenocarcinoma.

¹HCC: AFP stain in 218 cases[16,29,30], GPC-3 stain in 56 cases[30], Hep Par 1 stain in 308 cases[16,29-32] and CK19 stain in 233 cases[16,29,33];

²HAC data source: Data based on our review in Table 2;

³Common GAC data source: AFP stain in 122 cases[34,35], GPC-3 stain in 118 cases[35], Hep Par 1 stain in 108 cases[22,32], CK19 stain in 384 cases[33,36];

⁴Common GAC means GAC except HAC.