Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses

Figure 5 Levels of 7 cytokines were measured simultaneously from mouse serum using Fluorescence Activated Cell Sorting. A-E: TNBS-induced colitis exhibits heightened Th1-Th17 response of a complex, dynamic cytokine network [interleukin (IL)-2, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, IL-17], and MSCs maintain the balance of T-lymphocytes. F, G: In the TNBS-MSC group, transplanted MSCs promote T-lymphocytes to secrete cytokines (IL-4, IL-10) which regulate their functions. ^aP < 0.05, ^bP < 0.01 vs control; ^cP < 0.05, ^dP < 0.01 vs TNBS-PBS. TNBS-MSC: Trinitrobenzene sulfonic acid-mesenchymal stem cells; TNBS-PBS: Trinitrobenzene sulfonic acid-phosphate-buffered saline.