Strategies to rescue steatotic livers before transplantation in clinical and experimental studies

Table 3 Animal models of hepatic steatosis for liver transplantation

Disease	Approaches	Description	Animals	Treatment time
NAFLD	Genetic	Cerebral leptin receptor deficiency	Rodent
	Dietary	High fat	Rodent	7 d
		High cholesterol	Rodent, rabbits	8-12 wk
		Cafeteria diet	Rodent	4-15 wk
		Choline/methionine-deficient	Rodent	7 d-6 wk
		High starch and fat free after fasting	Rodent	4 d
		High fat and choline deficiency	Dog	8-12 wk
		High fat and high cholesterol, plus choline deficiency or not	Miniature pig	24 wk
		High fat and carbohydrate with streptozotocin for a diabetic state	Landrace pig	5 wk
AFLD	Dietary	Ethanol in liquid diet, intragastric infusion or gavage	Rodent	20 h-9 wk
		Ethanol and high fat diet	Rodent	6 wk
		Ethanol and deficient folate diet	Micropig	12 wk

NAFLD: Non-alcoholic fatty liver disease; AFLD: Alcoholic fatty liver disease.