Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells

Figure 3 Up-regulation of Delta-like ligand 4 promoted cell migration and invasion in SGC7901 cells. A: Crystal violet staining revealed the migrated cells of each group; B: Crystal violet staining reveals invaded cells from each of the groups; C: The number of cells in the SGC7901-Delta-like ligand 4 (DLL4) group that had migrated was 8.31 times higher than those transfected with an empty vector (205.4 ± 15.2 vs 22.3 ± 12.1, ^aP < 0.05); D: The number of cells in the SGC7901-DLL4 group that had migrated across both the Matrigel and the insert was 2.83 times higher than that in the SGC7901-vector group (68.8 ± 5.3 vs 18.2 ± 6.0, ^aP < 0.05). SGC7901-vector: SGC7901 cells transfected with an empty vector; SGC7901-DLL4: SGC7901 cells transfected with vector encoding human DLL4 gene; Control: Non-transfected SGC7901 cells.