Fibroblast growth factor receptor 4 Gly388Arg polymorphism in Chinese gastric cancer patients

Table 4 Influence of fibroblast growth factor receptor 4 Gly388Arg polymorphism on gastric cancer survival

	Totaln = 257	Gly/Glyn = 100	Gly/Arg + Arg/Argn = 157	Log rankχ2value	P value
Age (yr)
< 60	98	37	61	1.459	0.227
≥ 60	159	63	96	1.734	0.188
Sex
Male	188	79	109	0.041	0.839
Female	69	21	48	0.018	0.894
Tumor size
≤ 3 cm	55	24	31	5.449	0.020
> 3 cm	202	76	126	0.308	0.579
Differentiation
G1 + G2	94	33	61	12.798	0.000
G3 + G4	163	67	96	2.637	0.104
Invasion depth
T1 + T2	46	19	27	4.745	0.029
T3 + T4	211	81	130	0.037	0.848
N stage
N0	73	24	49	6.647	0.010
N1 + N2 + N3	184	76	108	0.024	0.876
M stage
M0	235	94	141	0.027	0.869
M1	22	6	16	0.139	0.710
Clinical stage
I + II	91	33	58	4.615	0.032
III + IV	166	67	99	0.048	0.827
Chemotherapy (5-fluorouracil and cisplatinum)
Yes	156	55	101	0.019	0.891
No	51	21	30	0.442	0.506
HER2 status
Negative	157	54	103	0.458	0.499
Positive	36	15	21	1.014	0.314

FGFR4: Fibroblast growth factor receptor 4; GC: Gastric cancer; HER2: Human epidermal growth factor receptor 2.